Temperature-Dependent Histotypic Changes in Walker Carcinosarcoma in the Chorioallantois

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Science  20 Sep 1963:
Vol. 141, Issue 3586, pp. 1181-1182
DOI: 10.1126/science.141.3586.1181


Solid tumors grew in the chorioallantois of chick embryos after the topical inoculation of ascites tumor cells. The microscopic character of the growth varied depending on the temperature of incubation. At 32.5°C a sarcomatous appearance was prominent; at 37.5°C carcinomatous structure in several alveolar patterns predominated; at 42.5°C growth was that of a "giant cell" carcinoma.