Thiamine: A Novel Conversion from Thiochrome

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Science  27 Sep 1963:
Vol. 141, Issue 3587, pp. 1280-1281
DOI: 10.1126/science.141.3587.1280


Reaction of thiochrome with with α-chloropropionic acid yields thiamine and acetaldehyde. The reaction seems to proceed by way of a zwitterion intermediate that undergoes decarboxylation and hydrolysis. The biological significance of the reaction cannot yet be evaluated.