Rubella Virus: Neutralizing Antibody in Commercial Gamma Globulin

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Science  04 Oct 1963:
Vol. 142, Issue 3588, pp. 58-60
DOI: 10.1126/science.142.3588.58


In 19 lots of standard commercial gamma globulin from humans, the titers of antibody neutralizing rubella virus varied from, 256 to 2048. The titers could not be correlated with geographic location of the donors, method of extraction, or tissue source. Samples of gamma globulin from rubella convalescents had titers of 4096. These titers were approximately 20 times higher than those in serum specimens from patients ill with natural or experimental infection. Serum antibody appears to persist for a number of years at nearly the original titers.