Freezing-Point Depression: New Method for Measuring Ultramicro Quantities of Fluids

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Science  11 Oct 1963:
Vol. 142, Issue 3589, pp. 237-239
DOI: 10.1126/science.142.3589.237


Accurate determination of the solute content of millimicroliter samples of biological fluids can conveniently be made with an instrument consisting of a thermoelectric cooler controlled by an electronic proportional servo system. Accuracies to within less than 2 percent have been achieved in determining the osmolarity of body fluids.