Reports

Polypeptide Chains of Rabbit Gamma Globulin

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Science  18 Oct 1963:
Vol. 142, Issue 3590, pp. 393-394
DOI: 10.1126/science.142.3590.393

Abstract

Rabbit gamma globulin has been extensively reduced, and its polypeptide chains separated by gel filtration on Sephadex G-200 in SM guanidine hydrochloride. The larger H (or A) chains make up two-thirds of the molecule and have a molecular weight of approximately 55,000 each. The smaller L (or B) chains account for the other one-third and have a molecular weight of approximately 25,000 each. The data are consistent with a model of the gamma globulin molecule that has two H and two L chains.