Genetic Differences in Antibody Production to Determinant Groups on Insulin

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Science  18 Oct 1963:
Vol. 142, Issue 3590, pp. 400-401
DOI: 10.1126/science.142.3590.400


Highly inbred strain 2 guinea pigs can produce antibodies to portions of the insulin molecule to which strain 13 guinea pigs cannot produce antibodies. Such differences were not observable within either strain. Consequently it is probable that genetic factors regulate antibody production with respect to the determinant groups toward which antibodies are directed.