Inhibition by 5-Iododeoxyuridine of the Oncogenic Effects of Adenovirus Type 12 in Hamsters

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Science  25 Oct 1963:
Vol. 142, Issue 3591, pp. 488-490
DOI: 10.1126/science.142.3591.488


Subcutaneous tumors induced in newborn hamsters by type 12 adenovirus were suppressed when 0.5 mg of 5-iodo-2'-deoxyuridine (IUdR) was given at the same subcutaneous site as the virus. Although one injection of IUdR given immediately after the virus was effective, additional injections on subsequent days reduced further the number of hamsters developing tumors. These effects of lUdR are especially interesting since replication of infectious adenovirus 12 cannot be demonstrated in the hamsters at any time before or after tumor development.