Abnormal Myoglobin Ultraviolet Spectrum in Duchenne Type of Progressive Muscular Dystrophy

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Science  25 Oct 1963:
Vol. 142, Issue 3591, pp. 490-491
DOI: 10.1126/science.142.3591.490


Met-myoglobin isolated from gluteal muscle of cases with Duchenne type of progressive muscular dystrophy showed an abnormal ultraviolet spectrum. The maximum of the spectrum at pH 7.0 was at 275 mµ, in contrast to that at 281 m/ A in normal met-myoglobin. Such an abnormality was not found in the limb-girdle type of dystrophy and in progressive spinal muscular atrophy. The results indicate the presence of an abnormal myoglobin in the Duchenne type of progressive muscular dystrophy.