Long-Term Isolation Stress in Rats

Science  25 Oct 1963:
Vol. 142, Issue 3591, pp. 507
DOI: 10.1126/science.142.3591.507


Rats isolated for long periods became nervous and aggressive and developed caudal dermatitis ( scaly tail). After 13 weeks of isolation, rats had heavier adrenals and thyroid and lighter spleen and thymus compared with rats kept in community cages. This indicates an endocrinopathy with hyperfunction of the adrenal cortex.