Hepatic Glucokinase: A Direct Effect of Insulin

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Science  01 Nov 1963:
Vol. 142, Issue 3592, pp. 590-591
DOI: 10.1126/science.142.3592.590


Particle-free extracts of the livers from rats on a normal diet were incubated with insulin for 4 minutes; during this time the glucokinase activity increased. This insulin effect is dependent upon the dose.