Genetic Alteration of Adenylic Pyrophosphorylase in Salmonella

Science  08 Nov 1963:
Vol. 142, Issue 3593, pp. 680-681
DOI: 10.1126/science.142.3593.680


A mutant of Salmonella typhimurium, resistant to inhibition by 2, 6-diaminopurine, differs from its sensitive wild-type parent by an altered adenylic acid pyrophosphorylase. The altered enzyme, though still active with adenine as substrate, is inactive in the conversion of diaminopurine to its nucleotide. It also differs from the wildtype enzyme in a number of physical and chemical properties.