Process of Infection with øX174: Effect of Exonucleases on the Replicative Form

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Science  15 Nov 1963:
Vol. 142, Issue 3594, pp. 962-963
DOI: 10.1126/science.142.3594.962


When a preparation containing the DNA of the bacteriophage øX174 in its replicative form together with DNA from Escherichia coli is treated with exonucleases, the replicative form retains its characteristic physical properties, while the bacterial DNA is degraded. The evidence suggests that the mature replicative form exists as a closed ring.