Lipoprotein Movement through Canine Aortic Wail

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Science  15 Nov 1963:
Vol. 142, Issue 3594, pp. 972-973
DOI: 10.1126/science.142.3594.972


Low-density (1.019 to 1.063) lipoprotein labeled with radioiodine enters the inner layer of the canine aortic wall directly from the aortic lumen. Its rate of entry is greatest in the proximal aorta and decreases progressively down the length of the aorta. A similar gradient was observed previously for the accumulation of cholesterol early in experimental atherosclerosis.