Convulsant Drug Action on Neuronally Isolated Cerebral Cortex

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Science  15 Nov 1963:
Vol. 142, Issue 3594, pp. 973-975
DOI: 10.1126/science.142.3594.973


After topical application of thiosemicarbazide, semicarbazide, or isoniazid to the surface of an isolated region of cortex, convulsive responses to electrical stimulation appeared only after a finite number of normal responses had been elicited, and disappeared again if stimulation was interrupted for about 10 minutes. With any of the other convulsant drugs tested, development of the convulsive pattern was independent of whether or not the cortex was stimulated. The two groups of drugs evidently have dijferent modes of action.