Hydroxyurea: Mechanism of Action

Science  22 Nov 1963:
Vol. 142, Issue 3595, pp. 1069-1070
DOI: 10.1126/science.142.3595.1069


Acetohydroxamic acid has been identified, by paper chromatography, in the blood of three patients with chronic myelogenous leukemia on hydroxyurea therapy. This suggests that the drug is hydrolyzed yielding hyroxylamine, which then cleaves thioesters, in particular acetyl-coenzyme A.