Inhibition of Adhesiveness and Aggregation of Dissociated Cells by Inhibitors of Protein and RNA Synthesis

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Science  22 Nov 1963:
Vol. 142, Issue 3595, pp. 1070-1071
DOI: 10.1126/science.142.3595.1070


Mutual adhesiveness and aggregation of dissociated embryonic retina cells in suspension cultures are suppressed rapidly and reversibly by puromycin, an inhibitor of RNA-dependent protein synthesis; and at a slower rate, irreversibly, by actinomycin D, an inhibitor of RNA formation. The results imply that biosynthetic processes are involved in the mechanism of reattachment of these cells.