Proteinpolysaccharide in Connective Tissue: Inhibition of Phase Separation

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Science  22 Nov 1963:
Vol. 142, Issue 3595, pp. 1073-1075
DOI: 10.1126/science.142.3595.1073


A macromolecule of protein and chondroitin sulfate (PP-L) inhibits sedimentation of barium-polystyrene sulfonate (BaPSS) and of calcium phosphate at low but not at high values of gravity. Sedimentation of BaPSS removes a large fraction of PP-L from solution, but sedimentation of calcium phosphate does not. The results suggest entanglement among linear polyanionic chains.