Reticuloendothelial Function and the Immune Response

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Science  22 Nov 1963:
Vol. 142, Issue 3595, pp. 1078-1080
DOI: 10.1126/science.142.3595.1078


Hyperphagocytic activity of the reticuloendothelial system induced in mice by the injection of glucan is associated with a significant increase in the primary and secondary immune responsiveness of these animals to sheep erythrocytes. Conversely, the administration of an agent which reduces endothelial phagocytosis is associated with significant depression of both primary and secnation of both factors.