Rationale for a Universal Genetic Code

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Science  22 Nov 1963:
Vol. 142, Issue 3595, pp. 1083-1085
DOI: 10.1126/science.142.3595.1083


A mutation in the genetic code would place new amino acids in certain loci and entirely eliminate amino acids from other loci of practically all proteins in an organism. It is reasonable to postulate that mutations of this kind cannot supplant the original code. The genetic code, once established, would therefore remain invariant.