Homograft Rejection in the Fetal Lamb: The Role of Circulating Antibody

Science  29 Nov 1963:
Vol. 142, Issue 3596, pp. 1172-1173
DOI: 10.1126/science.142.3596.1172


Specific rejection of sterile orthotopic skin homografts by the fetal lamb in utero was unaccompanied by the presence of plasma cells in either the graft and its bed, or in the reactive draining lymph node. The grafts appeared not to stimulate the production of circulating immunoglobulins. The presence in the fetal circulation of rabbit anti-sheep 7S γ-globulin and anti-β2M-globulin did not inhibit the normal course of homograft rejection. These data support the contention that conventional circulating antibody is not an obligatory participant in the rejection of solid-tissue homografts.