Erythroid Homeostasis in Normal and Genetically Anemic Mice: Reaction to Induced Polycythemia

See allHide authors and affiliations

Science  13 Dec 1963:
Vol. 142, Issue 3598, pp. 1468-1469
DOI: 10.1126/science.142.3598.1468


After hypertransfusion, normal ww and anemic WWT mice show the same increase in red-cell volume, decrease in reticulocytes, and temporary cessation of blood formation. The time required for the red cell volume to return to the value observed before treatment is the same for both groucps of inice. The cell volume at which new erythrocytes are again released into the circulation depends upon the genotype of functioning blood-forming tissue. Injections of erythropoietin stimulate red cell formation in polycythemic ww mice, but have much less (if any) effect upon polycythemic WWT mice.