Inhibition of Growth of Chick Embryo by Inhibition of Deoxycytidylate Deaminase

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Science  13 Dec 1963:
Vol. 142, Issue 3598, pp. 1473-1474
DOI: 10.1126/science.142.3598.1473


Deoxyguanylate when added to chick embryos grown in explant inhibited growth and development. Deoxycytidylate deaminase activity was inhibited both in the explants and in vitro; since the effect was quite specific, it is suggested that this may represent another control mechanism for deoxynucleotide synthesis.