Polyribosomes: Size in Normal and Polio-Infected HeLa Cells

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Science  27 Dec 1963:
Vol. 142, Issue 3600, pp. 1658-1663
DOI: 10.1126/science.142.3600.1658


HeLa cells normally contain a distribution of polysome sizes, and the largest polysomes contain over 40 ribosomes. After infection with polio virus and actinomycin-D treatment, a new class of polio-induced polysomes are found, some of which contain up to 60 ribosomes. Examinaton of these polysomes suggests a mechanism for protein synthesis with this polycistronic RNA.