Activity Rhythm in Peromyscus: Its Influence on Rates of Recovery from Nembutal

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Science  27 Dec 1963:
Vol. 142, Issue 3600, pp. 1682-1683
DOI: 10.1126/science.142.3600.1682


Injection of sublethal doses of Nembutal (sodium pentobarbital) into deer mice, Peromyscus maniculatus rufinus (Merriam), at diflerent times in their daily activity cycle revealed large differences in rates of recovery. By taking the phase of the circadian rhythm into account, the accuracy obtained in pharmaceutical and physiological bioassays could be increased.

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