Antibody Suppression by Antigen Heavily Labeled with Iodine-131

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Science  10 Jan 1964:
Vol. 143, Issue 3602, pp. 132-133
DOI: 10.1126/science.143.3602.132


Antibody formation in rabbits was suppressed by tobacco mosaic virus heavily labeled with iodine-131. Animals were injected intravenously with virus containing 0.5 to 4.4 mc of l131 and after a period of 6 days were challenged with a new antigen, γglobulin. Most irradiated animals did not produce detectable antibody. No signs of radiation sickness were noted.