Ethacrynic Acid: Diuretic Property Coupled to Reaction with Sulfhydryl Groups of Renal Cells

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Science  10 Jan 1964:
Vol. 143, Issue 3602, pp. 133-134
DOI: 10.1126/science.143.3602.133


Ethacrynic acid, injected intravenously after surgical removal of one kidney of anesthetized dogs, lowered the concentration of protein-bound sulfhydryl groups in cells of the remaining kidney. Chloride excretion and urinary output of the kidney exposed to the drug increased. These findings indicate that the diuresis produced by ethacrynic acid may be related to its capacity for binding sulfhydryl groups of renal cellular proteins.