Hemoglobin Solubility and α-Chain Structure in Crosses between Two Inbred Mouse Strains

Science  17 Jan 1964:
Vol. 143, Issue 3603, pp. 252-253
DOI: 10.1126/science.143.3603.252


In genetic crosses between mouse strains with low and high solubilities of hemoglobin, solubility segregated as a Mendelian unit and appeared to be determined by the alleles controlling α-chain structure. New data eliminate close linkage between the α-chain locus and genetic markers in linkage groups Ill, IV, XI, XIII, and XVI. Simplified methods are presented for screening differences inα-chain peptides and solubility.