Structure of Lipoproteins: Covalently Bound Fatty Acids

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Science  24 Jan 1964:
Vol. 143, Issue 3604, pp. 362-363
DOI: 10.1126/science.143.3604.362


Plasma lipoproteins, extensively extracted with organic solvents, contain small quantities of firmly bound long-chain fatty acids. Upon enzymatic digestion of the protein and partial purification of the resulting peptides, fatty acids are found associated with a peptide fraction which contains organic phosphate. The nature of the linkage between the fatty acid and peptide is unknown.