Calciphylaxis: Passive Transfer

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Science  24 Jan 1964:
Vol. 143, Issue 3604, pp. 365-366
DOI: 10.1126/science.143.3604.365


Rats were sensitized by mouth with dihydrotachysterol and subsequently challenged by a subcutaneous injection of ferric dextran. Mineralization at the injection site is barely detectable 17 hours after challenge. If, at this time, the challenged skin is transplanted onto a normal recipient, mineralization continues in the nonsensitized host. Sensitization is indispensable only for the initiation of the calciphylactic response and, once "triggered," the mechanism for this type of mineralization is transferable.