Oxidation of Carbon-14-Labeled Endogenous Lipids by Isolated Perfused Rat Heart

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Science  24 Jan 1964:
Vol. 143, Issue 3604, pp. 371-373
DOI: 10.1126/science.143.3604.371


Lipids of the rat heart were labeled with carbon-14 in vivo. The production of C14O2 during the subsequent perfusion of these glycogen-depleted hearts with buffer, but without added substrate, provided direct evidence of the oxidation of endogenous heart lipids. The net decrease in phospholipid content alone could account for 75 percent of the total metabolic CO2 formed.