Growth Inhibition of Sarcoma and Carcinoma Cells of Homozygous Origin

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Science  31 Jan 1964:
Vol. 143, Issue 3605, pp. 477-478
DOI: 10.1126/science.143.3605.477


Three sarcomas and one carcinoma, originating in homozygous mice, were tested for growth in isologous animals and various semi-isologous F1 hybrids after inoculation of 103 to 105 cells. Findings indicated the existence of an "F1 hybrid effect" for sarcomas and carcinomas, as previously described for lymphomas and normal hematopoietic cells, there being a lower tumor frequency and a longer latency period in the hybrids than in isologous mice.