Allelic Mapping in Yeast by X-ray-Induced Mitotic Reversion

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Science  07 Feb 1964:
Vol. 143, Issue 3606, pp. 581-582
DOI: 10.1126/science.143.3606.581


A new method for determining the sequence of mutational sites is based on the linear dose-effect relation for x-ray induction of allelic recombination in Saccharomyces cerevisiae. Mutations at two loci have been mapped by this method. The use of x-ray simplifies allelic mapping and greatly increases its sensitivity.