Alpha-Chain of Human Hemoglobin: Occurrence in vivo

Science  07 Feb 1964:
Vol. 143, Issue 3606, pp. 590-591
DOI: 10.1126/science.143.3606.590


A minor hemoglobin component, apparently representing uncombined α-chains has been detected in the hemolysates of persons with inherited β-chain deficiency of moderate or severe degree. This finding supports the hypothesis that there is independent control of the synthesis of α-chains.