Autoradiographic Distribution of Radioactive Sodium in Rat Kidney

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Science  14 Feb 1964:
Vol. 143, Issue 3607, pp. 695-696
DOI: 10.1126/science.143.3607.695


A utoradiographs of kidney sections from rats injected with sodium 22 showed two areas of relatively high concentration of the radioisotope. The first area appeared in the outer medulla; the second appeared as an area of increasing concentration toward the papilla. Autoradiographs of sections labeled with chloride-36 appeared essentially the same. Autoradiographs of sections labeled with inulin-C14OOH showed an increased concentration in the inner medulla. These results may have a bearing on the counter-current multiplier hypothesis for the production of concentrated urine.