Inhibition of Synthesis of the Cell Wall of Staphylococcus aureus by Cephalothin

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Science  21 Feb 1964:
Vol. 143, Issue 3608, pp. 807-808
DOI: 10.1126/science.143.3608.807


Cephalothin, 7-(thiophene-2-acetamido)-cephalosporanic acid, suppresses synthesis of the cell of Staphylococcus aureus. Exposure to this agent led to a reduction in the degree of incorporation of carbon-14-lysine into the mucopeptide of the cell wall material and to an accumulation of N-acetyl glucosamine in the cell. The intensity of the lesions was comparable to that produced by penicillin.