Lymphocyte Interaction: A Potential Histocompatibility Test in vitro

See allHide authors and affiliations

Science  21 Feb 1964:
Vol. 143, Issue 3608, pp. 813-814
DOI: 10.1126/science.143.3608.813


Lymphocytes from two unrelated individuals, cultured together in the same tube, undergo morphological transformation to large cells and divide. Both of these parameters may be estimated quantitatively. There is a correlation between the degree of this response and the degree of cross-reactivity of grafts from the two individuals placed on a third unrelated recipient.