Reports

Lymphocyte Interaction: A Potential Histocompatibility Test in vitro

Science  21 Feb 1964:
Vol. 143, Issue 3608, pp. 813-814
DOI: 10.1126/science.143.3608.813

Abstract

Lymphocytes from two unrelated individuals, cultured together in the same tube, undergo morphological transformation to large cells and divide. Both of these parameters may be estimated quantitatively. There is a correlation between the degree of this response and the degree of cross-reactivity of grafts from the two individuals placed on a third unrelated recipient.

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