Radioactive Myoinositol: Incorporation into Streptomycin

See allHide authors and affiliations

Science  28 Feb 1964:
Vol. 143, Issue 3609, pp. 953-954
DOI: 10.1126/science.143.3609.953


Radioactive myoinositol was rapidly incorporated into streptomycin by Streptomyces griseus. All the incorporated radioactivity was found in the streptidine moiety of the antibiotic, as shown by chemical degradation of the streptomycin. To a certain extent inositol reversed the depressing effect of phosphate on the production of the antibiotic.