Wasting Disease Induced in Young Mice by Administration of Cortisol Acetate

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Science  28 Feb 1964:
Vol. 143, Issue 3609, pp. 965-966
DOI: 10.1126/science.143.3609.965


A single injection of cortisol acetate into young mice induced a wasting syndrome similar to that observed in runt disease and in the post-thymectomy syndrome. The course of the disease was less severe if the dose of the drug was decreased or if the animals were older at the time of injection.