Virus-Specific Double-Stranded RNA in Poliovirs-Infected Cells

Science  06 Mar 1964:
Vol. 143, Issue 3610, pp. 1034-1036
DOI: 10.1126/science.143.3610.1034


Poliovirus-infected HeLa cells contain a small amount of an RNA that sediments slightly faster than 16S. This RNA is less dense than viral RNA and resists digestion by ribonuclease. It is therefore, considered to be a double-stranded form of poliovirus RNA. A significant amount of this material is found in association with a membranous virus-specific particulate.