Gamma Hydroxybutyrate and Gamma Butyrolactone: Concentration in Rat Tissues during Anesthesia

Science  06 Mar 1964:
Vol. 143, Issue 3610, pp. 1045-1047
DOI: 10.1126/science.143.3610.1045


Gamma-hydroxybutyric acid, when administered to animals or human beings, causes sleep. It is convertible to gamma-butyrolactone, which also produces sleep. Tissue concentrations in rats after administration of these two compounds show that the induced sleep is related to the concentration of the lactone in the brain.