Amino Acid Code in Alcaligenes faecalis

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Science  13 Mar 1964:
Vol. 143, Issue 3611, pp. 1174-1176
DOI: 10.1126/science.143.3611.1174


Amino acid incorporation into protein, promoted by synthetic polynucleotides, was studied in a cell-free extract of Alcaligenes faecalis (combined guanine and cytosine content of DNA, 66 percent). In the limited survey, 18 code triplets were found to specify the amino acids as in Escherichia coli (combined guanine and-cytosine content of DNA, 52 percent). At least six of the eight possible triplets containing adenine and uracil were meaningful. No exceptions to the universality of the amino acid code were found.