Nocturnal Changes in Oxidative Activities of Rat Liver Mitochondria

See allHide authors and affiliations

Science  13 Mar 1964:
Vol. 143, Issue 3611, pp. 1184-1185
DOI: 10.1126/science.143.3611.1184


Male rats kept on an artificial day-night cycle were active at night and rested during the day. The rate of succinate oxidation in liver mitochondria from these animals was 40 percent greater at night. Significant nocturnal increases in the ratio of phosphate to oxygen were obtained with citrate, α-ketoglutarate, and malate.