Reports

6-Aminopenicillanic Acid: Inhibition of Destruction of Cephalosporin C by Bacteria

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Science  27 Mar 1964:
Vol. 143, Issue 3613, pp. 1438-1439
DOI: 10.1126/science.143.3613.1438

Abstract

6-Aminopenicillanic acid, from which all the true penicillins are derived, inhibits the destruction of cephalosporin C by certain microorganisms. This inhibition is probably specific for "cephalosporinase." The enzymatic deacetylation of cephalosporin C is not affected by the acid.