Reports

Actinomycin D: Suppression of Recovery in X-Irradiated Mammalian Cells

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Science  27 Mar 1964:
Vol. 143, Issue 3613, pp. 1454-1457
DOI: 10.1126/science.143.3613.1454

Abstract

The lethal effect of two x-ray doses can be considerably enhanced if cultured cells are exposed to actinomycin D between doses. Net survival can be modified by temperature as well as actinomycin treatment. These effects are related to repair of sublethal damage and to cell kinetics between doses.