Alpha-Ketoglutaric Semialdehyde: A Metabolic Intermediate

Science  03 Apr 1964:
Vol. 144, Issue 3614, pp. 67-68
DOI: 10.1126/science.144.3614.67


α-Ketoglutaric semialdehyde has been obtained as a product of hydroxyproline through reactions catalyzed by purified enzymes from Pseudomonas. It has been characterized both by chemical and enzymatic derivatives and by comparison with the chemically synthesized compound. This reactive compound, not previously known as a product of biological reactions, may participate in other metabolic pathways.

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