Estrone Inhibition of Cholesterol Biosynthesis at the Mevalonic Acid Stage

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Science  17 Apr 1964:
Vol. 144, Issue 3616, pp. 301-302
DOI: 10.1126/science.144.3616.301


Studies on the synthesis of cholesterol with cell-free homogenates of liver from rats treated with graded doses of estrone show that, at doses of estrone which cause a reduction in blood cholesterol, there is an accompanying inhibition of cholesterol biosynthesis. Furthermore, this inhibition appears to occur at the stage of cholesterol biosynthesis at which mevalonate is decarboxylated.

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