Nicotinic Acid Analogs: Effects on Response of Chick Embryos and Hens to Organophosphate Toxicants

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Science  01 May 1964:
Vol. 144, Issue 3618, pp. 539-540
DOI: 10.1126/science.144.3618.539


Embryonic abnormalities are known to be induced in chick embryos when they are injected with certain organophosphate insecticides prior to incubation. The marked teratogenic effects of Bidrin [3-(dimethoxyphosphinyloxy) N, N-dimethyl-cis-crotonamide] can be alleviated by many analogs of nicotinamide and nicotinamide adenine dinucleotide. Successive hydroxylation and N-dealkylation of Bidrin in the egg are not greatly altered by injection of nicotinamide. The delayed neurotoxicity in adult hens after administering tri-o-cresyl phosphate is also partially relieved by administering certain nicotinamide analogs.