Hemoglobins A and F: Formation in Thalassemia and Other Hemolytic Anemias

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Science  01 May 1964:
Vol. 144, Issue 3618, pp. 552-553
DOI: 10.1126/science.144.3618.552


Rates of synthesis of hemoglobin A by erythroid cells from thalassemic subjects are markedly decreased. Formation of hemoglobin F, however, proceeds at similar rates in cells from subjects with thalassemia and other types of hemolytic anemias. A mechanism is suggested regarding the altered patterns of hemoglobin synthesis under conditions of erythropoietic stimulation in subjects with and without thalassemia.