Spleen-Colony Formation in Anemic Mice of Genotype WW

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Science  15 May 1964:
Vol. 144, Issue 3620, pp. 844-846
DOI: 10.1126/science.144.3620.844


The hemopoietic cells from anemic mice of genotype WW are less able by 200-fold to take part in colony formationin the spleen than cells from the normal littermates of genotype ww. The genetic defect shows itself in the colony-forming cells, since cells from normal littermate mice formcolonies in the spleens of unirradiated mice of genotype WW. Use of animals of genotype WVVWT as recipients improves the spleen-colony method by removing bias resulting fromthe death of irradiated recipients.