Immunologically Determined and Competent Cells Are Affected Differentially by Actinomycin D

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Science  15 May 1964:
Vol. 144, Issue 3620, pp. 846-849
DOI: 10.1126/science.144.3620.846


A differential effect of actinomycin D on the capacity of mouse peritoneal fluid cells to form antibody after cell transfer has been found. Actinomycin treatment in vitro during transfer inhibited the delayed response toward a first antigen, administered before transfer, while the competence of cells to respond to a second antigen, given aftertransfer, was not affected.